Gout, hyperuricaemia, sleep apnoea-hypopnoea syndrome and vascular risk
| Autor: | Miguel Cantalejo Moreira, Raul Maria Veiga Cabello, Antonio Zapatero Gaviria, Vanesa García Díaz, Miguel Ángel Racionero Casero |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Gout Polysomnography Hyperuricemia Vascular risk chemistry.chemical_compound Sleep Apnea Syndromes Rheumatology Risk Factors Surveys and Questionnaires Internal medicine medicine Humans Pharmacology (medical) cardiovascular diseases Aged medicine.diagnostic_test business.industry nutritional and metabolic diseases Apnea Middle Aged Osteoarthritis Knee medicine.disease nervous system diseases Surgery Obstructive sleep apnea chemistry Cardiovascular Diseases Uric acid Female medicine.symptom business |
| Zdroj: | Rheumatology. 52:1619-1622 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objective. This study aimed to evaluate cardiovascular (CV) and atherothrombosis risk factors in patients with gout and hyperuricaemia with suspected sleep apnoeahypopnoea syndrome (SAHS) compared with a control group of subjects with knee OA and SAHS. Methods. Clinical information on CV risk factors and atherothrombosis was collected in a rheumatology department in patients with gout and hyperuricaemia and suspicion of SAHS. Confirmation polysomnography that registered apnoeahypopnoea index (AHI) and oxygen saturation during sleep (SaO2) was performed. The control group consisted of patients with OA and polysomnographically confirmed SAHS. Results. In the gout patient group (54 patients, 48 men), CV risk factors were found in 77.8% and evidence of atherothrombosis in 46.3%. In the OA group (36 patients, 27 men), CV risk factors were found in 66.7% and evidence of atherothrombosis in 0%. SAHS diagnosis was confirmed by polysomnography in 88.9% of patients. AHI showed mild, moderate and severe SAHS in 12%, 26% and 66% of the gout patients and 45%, 24% and 30% of the OA patients, respectively. SaO2 was 90.18% in the gout group and 91.26% in the OA group. Conclusion. Patients with gout and hyperuricaemia and suspicion of SAHS had polysomnographically confirmed SAHS in 88.9% of cases. These patients had more severe forms of SAHS and a greater prevalence of documented atherothrombotic disease compared with a control group with OA. |
| Databáze: | OpenAIRE |
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