Significance of 5-S-Cysteinyldopa as a Marker for Melanoma
| Autor: | Hisashi Uhara, Ryuhei Okuyama, Naohito Hatta, Kazumasa Wakamatsu, Tokimasa Hida, Hironobu Ihn, Akane Minagawa, Satoshi Fukushima, Minoru Takata, Toshikazu Omodaka |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Skin Neoplasms Review Disease Scintigraphy lcsh:Chemistry 0302 clinical medicine early detection lcsh:QH301-705.5 Spectroscopy medicine.diagnostic_test Incidence (epidemiology) Melanoma General Medicine Computer Science Applications Cysteinyldopa 030220 oncology & carcinogenesis Metabolome hepatocyte growth factor (hgf) biomarker Biomarker (medicine) Sample collection Drug Monitoring s100 calcium-binding protein b (s100b) medicine.medical_specialty Early detection Catalysis Inorganic Chemistry 03 medical and health sciences Internal medicine Biomarkers Tumor melanoma medicine Humans lactate dehydrogenase (ldh) Physical and Theoretical Chemistry 5-s-cysteinyldopa (5scd) melanoma inhibitory activity (mia) Molecular Biology 5-S-cysteinyldopa business.industry Organic Chemistry medicine.disease 030104 developmental biology anti-programmed cell death protein (pd)-1 antibody lcsh:Biology (General) lcsh:QD1-999 5-S-cysteinyldopa (5SCD) business |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 2, p 432 (2020) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21020432 |
| Popis: | Melanoma is one of the most lethal and malignant cancers and its incidence is increasing worldwide, and Japan is not an exception. Although there are numerous therapeutic options for melanoma, the prognosis is still poor once it has metastasized. The main concern after removal of a primary melanoma is whether it has metastasized, and early detection of metastatic melanoma would be effective in improving the prognosis of patients. Thus, it is very important to identify reliable methods to detect metastases as early as possible. Although many prognostic biomarkers (mainly for metastases) of melanoma have been reported, there are very few effective for an early diagnosis. Serum and urinary biomarkers for melanoma diagnosis have especially received great interest because of the relative ease of sample collection and handling. Several serum and urinary biomarkers appear to have significant potential both as prognostic indicators and as targets for future therapeutic methods, but still there are no efficient serum and urinary biomarkers for early detection, accurate diagnosis and prognosis, efficient monitoring of the disease and reliable prediction of survival and recurrence. Levels of 5-S-cysteinyldopa (5SCD) in the serum or urine as biomarkers of melanoma have been found to be significantly elevated earlier and to reflect melanoma progression better than physical examinations, laboratory tests and imaging techniques, such as scintigraphy and echography. With recent developments in the treatment of melanoma, studies reporting combinations of 5SCD levels and new applications for the treatment of melanoma are gradually increasing. This review summarizes the usefulness of 5SCD, the most widely used and well-known melanoma marker in the serum and urine, compares 5SCD and other useful markers, and finally its application to other fields. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|