The study of influence of crosslinking and organic additives on the behavior of chitosan gels

Autor:	Marconi F. Ginani, Marco V. M. Navarro, Uazir O. B. de Oliveira, Ednaldo Gomes do Nascimento
Rok vydání:	1999
Předmět:	gel Formaldehyde Natural polymers General Chemistry Controlled release lcsh:Chemistry Chitosan Chemistry chemistry.chemical_compound lcsh:QD1-999 chemistry polysaccharide Polymer chemistry medicine Glutaraldehyde chitosan Swelling medicine.symptom QD1-999 Nuclear chemistry
Zdroj:	Química Nova v.22 n.6 1999 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ Química Nova, Vol 22, Iss 6, Pp 801-804 (1999) Química Nova, Volume: 22, Issue: 6, Pages: 801-804, Published: DEC 1999
ISSN:	0100-4042
Popis:	The physical-chemical process of swelling in water-based gel of natural polymers is investigated with the purpose of applying these systems to biomedical materials for controlled release of drugs. In this work we develop a study about the sol-gel transition of solutions of chitosan in the presence of formaldehyde and glutaraldehyde like crosslinking agents and we have determined the effect of many aditives in the time of gelification from the elaborated sistems. The phisical-chemistry process of swelling of the formed gels was evaluated in function of the degree of crosslinking of the incorporated aditives and the pH. Gelling times of chitosan solutions were obtained using viscosimetric measurement, in the pre-gel state, as well as condutivity ones.The results obtained suggest that component concentration modifies the kinetic profile of the transition and the swelling behavior. Regarding H+ content, the gels were highly susceptible to swelling in acidic conditions, which characterize this system as pH - sensitive.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e29dce945e319c4df8e83a81382edf https://doi.org/10.1590/s0100-40421999000600005 Zobrazit plný text záznamu