Effects of maternal captopril treatment during late pregnancy on neonatal lung development in rats

Autor:	Susana I. Sánchez, Diego N. Capelari, Gladys Maria Ciuffo, Hugo Hector Ortega, Lucia B. Fuentes
Rok vydání:	2011
Předmět:	Male medicine.medical_specialty Captopril Physiology Clinical Biochemistry Angiotensin-Converting Enzyme Inhibitors Peptidyl-Dipeptidase A Biochemistry Receptor Angiotensin Type 1 Renin-Angiotensin System Cellular and Molecular Neuroscience Endocrinology Pregnancy Internal medicine Proliferating Cell Nuclear Antigen Pulmonary fibrosis Weight Loss medicine Animals Rats Wistar Myofibroblasts Lung Cell Proliferation biology Angiotensin-converting enzyme Cell Differentiation Organ Size medicine.disease Pulmonary hypertension Actins Proliferating cell nuclear antigen Rats medicine.anatomical_structure Bronchopulmonary dysplasia Animals Newborn Prenatal Exposure Delayed Effects biology.protein Female Biomarkers medicine.drug
Zdroj:	Regulatory peptides. 177(1-3)
ISSN:	1873-1686
Popis:	The renin-angiotensin system (RAS) has been implicated in pulmonary hypertension and pulmonary fibrosis. In the present study, we examined the effects of maternal exposure to captopril (2.85 mg/kg/day) during late pregnancy (G13-G21) on postnatal rat lung development. Treatment with captopril during late pregnancy caused a significant decrease in ACE activity in P0 rats. Body weight decreased at P0 (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02de8aaa4853466968429fb512bd2bb8 https://pubmed.ncbi.nlm.nih.gov/22587910 Zobrazit plný text záznamu Full Text from ScienceDirect