Serum uric acid levels and risk for acute ischaemic nonembolic stroke in elderly subjects
| Autor: | Dimitri P. Mikhailidis, Kallirroi Kalantzi, John A. Goudevenos, Haralampos J. Milionis, Moses Elisaf, K. Seferiadis |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Population Body Mass Index Brain Ischemia Sex Factors Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans Risk factor education Stroke Aged Metabolic Syndrome Univariate analysis education.field_of_study business.industry Case-control study Odds ratio medicine.disease Lipids Uric Acid Surgery Case-Control Studies Hypertension Female business Body mass index |
| Zdroj: | Journal of Internal Medicine. 258:435-441 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1111/j.1365-2796.2005.01565.x |
| Popis: | Background. Elevated serum uric acid (SUA) levels have been proposed as an independent risk factor for cardiovascular (CV) morbidity and mortality. Recent evidence suggests that treatments with a hypouricaemic action have a favourable effect on CV event prevention. Objectives. The association between SUA and acute ischaemic/nonembolic stroke was assessed in a population-based case–control study in the prefecture of Ioannina, Epirus, Greece. Subjects and methods. A total of 163 patients aged older than 70 years (88 men and 75 women) admitted due to a first-ever-in-a-lifetime acute ischaemic/nonembolic stroke and 166 volunteers (87 men and 79 women) without a history of CV disease were included. The association between SUA and stroke was determined by multivariate logistic regression modelling after adjusting for potential confounding factors. Results. Stroke patients showed higher concentrations of SUA compared with controls (333.1 ± 101.1 μmol L−1 vs. 285.5 ± 83.3 μmol L−1; P |
| Databáze: | OpenAIRE |
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