The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation
| Autor: | Rüdiger Göke, Brigitte Lankat-Buttgereit |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Programmed cell death
Cell type RNA-Binding Proteins Cell Biology General Medicine Cell cycle Biology law.invention Cell biology law Transcription (biology) Neoplasms Cancer research Animals Humans Suppressor Genes Tumor Suppressor Programmed Cell Death Protein 4 Signal transduction Apoptosis Regulatory Proteins Gene Signal Transduction |
| Zdroj: | Biology of the Cell. 101:309-317 |
| ISSN: | 0248-4900 |
| DOI: | 10.1042/bc20080191 |
| Popis: | Pdcd4 (programmed cell death 4) has been known as a tumour suppressor gene and potential target for anticancer therapies for several years. Initially, Pdcd4 was identified as a gene that is up-regulated during apoptosis, but its precise role still remains to be defined. However, there is increasing evidence that Pdcd4 levels influence transcription, as well as translation, modulate different signal transduction pathways and might act as a tumour suppressor. Interestingly, recent data suggest that Pdcd4 function may depend on cell type and/or genetic background. This review summarizes the current knowledge regarding the function and regulation of Pdcd4. |
| Databáze: | OpenAIRE |
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