Thymic Epithelial Tumors as a Model of Networking: Development of a Synergistic Strategy for Clinical and Translational Research Purposes
Autor: | Nicolas Girard, Mirella Marino, Gabriele Alessandrini, Laura Conti, Mauro Caterino, Giovannella Palmieri, Fabiana Letizia Cecere, Nicoletta De Bello, Enzo Gallo, Marina Chiara Garassino, Paolo Visca, Gennaro Ciliberto, Beatrice Casini, Federica Ganci, Francesco Facciolo, Francesco Fazi, Rossano Lattanzio, Simona di Martino, Chiara Mandoj, Valentina Laquintana, Giovanni Blandino, Enrico Melis, Filippo Tommaso Gallina, Edoardo Pescarmona, Arianna Papadantonakis |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Cancer Research Thymoma Basic science biobank EURACAN ITMIG microRNA TCGA thymic carcinoma thymic epithelial tumors thymoma Translational research Malignancy lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Methods Functional studies Thymic carcinoma business.industry medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Biobank 030104 developmental biology 030220 oncology & carcinogenesis Differential diagnosis business |
Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 10 (2020) |
ISSN: | 2234-943X |
Popis: | Among the group of thymic epithelial tumors (TET), thymomas often show either uncertain or explicit malignant biological behavior, local invasiveness, and intrathoracic relapse and are often difficult to manage. From the initial stages, thymic carcinomas tend to show aggressive behavior and extrathoracic spread. Moreover, the interplay of epithelial cells and thymocytes in thymomas causes complex immune derangement and related systemic autoimmune diseases. Due to their rare occurrence and to the limited funding opportunities available for rare tumors, it is challenging to make advances in clinical and translational research in TET. The authors of this paper are all members of a multidisciplinary clinical and research thoracic tumor team. Strong input was given to the team by long-standing expertise in TET in the Pathology Department. In addition, thanks to the collaboration between research units at our Institute as well as to national collaborations, over the last 10 years we were able to perform several tissue-based research studies. The most recent studies focused on microRNA and on functional studies on the thymic carcinoma cell line 1889c. The recent implementation of our biobank now provides us with a new tool for networking collaborative research activities. Moreover, the participation in a worldwide community such as ITMIG (International Thymic Malignancy Interest Group) has allowed us to significantly contribute toward fundamental projects/research both in tissue-based studies (The Cancer Genome Atlas) and in clinical studies (TNM staging of TET). Our achievements derive from constant commitment and long-standing experience in diagnosis and research in TET. New perspectives opened up due to the establishment of national [the Italian Collaborative Group for ThYmic MalignanciEs (TYME)] and European reference networks such as EURACAN, for an empowered joint clinical action in adult solid rare tumors. The challenge we face still lies in the advancement of clinical and basic science in thymic epithelial malignancies. |
Databáze: | OpenAIRE |
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