Anti-Angiogenesis Activities of Novel Peptide Complexes: Mitochondria-Disruptive 9mer Peptides Conjugated with the Integrin alpha V beta 3-Homing Cyclic RGD Motif
| Autor: | Jun Ishibashi, Ai Asaoka, Tsuyoshi Kawano, Minoru Yamakawa, Takashi Iwasaki |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Alpha-v beta-3
media_common.quotation_subject Amino Acid Motifs Integrin Angiogenesis Inhibitors Apoptosis Peptide Peptides Cyclic Applied Microbiology and Biotechnology Biochemistry Umbilical vein Analytical Chemistry chemistry.chemical_compound Cell Line Tumor Chlorocebus aethiops Animals Humans Amino Acid Sequence Cytotoxicity Internalization Molecular Biology Peptide sequence media_common Membrane Potential Mitochondrial chemistry.chemical_classification Drug Carriers biology Organic Chemistry General Medicine Integrin alphaVbeta3 Mitochondria Protein Transport Gene Expression Regulation chemistry COS Cells Drug delivery biology.protein Oligopeptides Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 76:2044-2048 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.120397 |
| Popis: | RGD peptides are popular drug delivery tools in treating integrin αVβ3-expressing malignant tumors and tumor vasculature cells. We investigated the specific delivery and pharmacological potential of enantiomeric mitochondria-disruptive peptides (RLYLRIGRR-NH(2), RLRLRIGRR-NH(2), ALYLAIRRR-NH(2), and RLLLRIGRR-NH(2)) after conjugation with an integrin αVβ3-homing peptide, cyclic pentameric RGD peptide. The cyclic RGD-conjugated mitochondria-disruptive peptides exhibited specific internalization, apoptosis induction, and cytotoxicity against integrin αVβ3-high-expressing human umbilical vein endothelial cells. Our findings indicate that these novel peptide complexes might prove good anti-angiogenesis reagents. |
| Databáze: | OpenAIRE |
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