Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models
| Autor: | Rosanna Supino, G Pratesi, C. Pisano, Rosanna Foderà, C. Rossi, M. De Cesare, Franco Zunino, Valentina Zuco, Fabiana Fosca Ferrara, Loredana Vesci |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Combination therapy medicine.drug_class Mice Nude Adamantane Mice Ovarian carcinoma Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Tumor Cells Cultured Animals Humans Retinoid Cisplatin Ovarian Neoplasms business.industry Biological activity Hematology medicine.disease Xenograft Model Antitumor Assays Endocrinology Oncology Apoptosis Cinnamates Toxicity Cancer research Female Ovarian cancer business medicine.drug |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 18(9) |
| ISSN: | 0923-7534 |
| Popis: | Background: The novel adamantyl retinoid ST1926 is a potent inducer of apoptosis in ovarian carcinoma cells. Since the pro-apoptotic effect is associated with activation of p53, in this study we have investigated the efficacy of combination of ST1926 with cisplatin, a DNA-damaging agent that is known to induce p53-dependent apoptosis. Materials and methods: The efficacy of ST1926 and its combination with cisplatin was evaluated in human ovarian carcinoma models, including resistant tumors. Results: Oral treatment with ST1926 alone caused a marginal tumor growth inhibition ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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