Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway
| Autor: | Yukio Fujiwara, Tadashi Hamasaki, Takahiro Yamamoto, Kazutaka Ohta, Naoki Shinojima, Ken Uekawa, Tatsuya Takezaki, Yoshihiro Komohara, Keitaro Kai, Shigeyuki Esumi, Akitake Mukasa, Jun-ichiro Kuroda |
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| Rok vydání: | 2021 |
| Předmět: |
STAT3 Transcription Factor
Cancer Research Interleukin-1beta Gene Expression Cell Line chemistry.chemical_compound Glioma medicine Humans Molecular Targeted Therapy Interleukin 8 STAT3 neoplasms Microglia biology Brain Neoplasms Chemistry Activator (genetics) Macrophages NF-kappa B Interleukin NF-κB Cell Biology medicine.disease nervous system diseases medicine.anatomical_structure Cancer research biology.protein Glioblastoma Tyrosine kinase Signal Transduction |
| Zdroj: | Human Cell. 35:226-237 |
| ISSN: | 1749-0774 |
| DOI: | 10.1007/s13577-021-00619-8 |
| Popis: | Glioblastoma is a glioma characterized by highly malignant features. Numerous studies conducted on the relationship between glioblastoma and the microenvironment have indicated the significance of tumor-associated macrophages/microglia (TAMs) in glioblastoma progression. Since interleukin (IL)-1β secreted by TAMs has been suggested to promote glioblastoma growth, we attempted to elucidate the detailed mechanisms of IL-1β in glioblastoma growth in this study. A phospho-receptor tyrosine kinase array and RNA-sequencing studies indicated that IL-1β induced the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B signaling. Glioblastoma cells stimulated by IL-1β induced the production of IL-6 and CXCL8, which synergistically promoted glioblastoma growth via signal transducer and activator of transcription-3 and nuclear factor-kappa B signaling. By immunohistochemistry, IL-1β expression was seen on TAMs, especially in perinecrotic areas. These results suggest that IL-1β might be a useful target molecule for anti-glioblastoma therapy. |
| Databáze: | OpenAIRE |
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