Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures
| Autor: | G.G.G. de Oliveira, Armando Fernandes, A. Feitosa, Patrícia Severino, Eliana B. Souto, Kahynna Cavalcante Loureiro |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Chlorpheniramine maleate and phenylephrine hydrochloride
Thermogravimetric analysis Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Dosage form 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Differential scanning calorimetry medicine Magnesium stearate Antipyretic Thermal analysis Chlorpheniramine Maleate Pharmacology Chromatography Thermogravimetric analysis (TGA) lcsh:RM1-950 Phenylephrine Hydrochloride 021001 nanoscience & nanotechnology 3. Good health Paracetamol lcsh:Therapeutics. Pharmacology chemistry Differential Scanning Calorimetry (DSC) Original Article 0210 nano-technology medicine.drug |
| Zdroj: | Saudi Pharmaceutical Journal, Vol 25, Iss 1, Pp 99-103 (2017) |
| ISSN: | 1319-0164 |
| DOI: | 10.1016/j.jsps.2016.05.001 |
| Popis: | Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1:1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Information recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the characterization of the drug/excipients interactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|