Phenethyl isothiocyanate protects against cyclophosphamide-induced nephrotoxicity via nuclear factor E2–related factor 2 pathway in rats
| Autor: | Ayşe Burçin Uyumlu, Basri Satılmış, Buğrahan Atıcı, Aslı Taşlıdere |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Exp Biol Med (Maywood) |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.1177/15353702221139206 |
| Popis: | Phenethyl isothiocyanate (PEITC), a secondary metabolite in Cruciferous plants, exerts chemopreventive and antioxidant effects. However, its therapeutic potential in cyclophosphamide (CP)-induced nephrotoxicity is not clear. So, we focused to research on the effect of PEITC against renal toxicity caused by CP and its relationship to the Nrf2 signaling mechanism. Thirty female Wistar albino rats were allocated to three groups: control ( n = 10), CP ( n = 10), and PEITC-pretreated group (150 µmol/kg b.w. orally; n = 10). The antioxidant enzyme activities and levels of malondialdehyde (MDA), sirtuin 1 (SIRT1), glutathione-S-transferase (GST), nuclear factor E2–related factor 2 (Nrf2), nuclear factor kappa B (NF-κB), serum urea, and creatinine (Cr) were measured. In the CP group, serum urea and Cr, MDA, and NF-κB levels have risen, and the activities of antioxidant enzymes and SIRT1, Nrf2, and GST levels have reduced significantly ( P |
| Databáze: | OpenAIRE |
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