Photoactive terthiophenes: the influence of serum on anti-HIV (human immunodeficiency virus) activities
| Autor: | John T. Arnason, L. Harris, Robin J. Marles, C. Soucy-Breau, James B. Hudson |
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| Rok vydání: | 1994 |
| Předmět: |
Carboxylic acid
Human immunodeficiency virus (HIV) Thiophenes Biology medicine.disease_cause Biochemistry Antiviral Agents Cell Line chemistry.chemical_compound Terthiophene Cytopathogenic Effect Viral medicine Humans Physical and Theoretical Chemistry chemistry.chemical_classification Photosensitizing Agents Singlet Oxygen Anti hiv Singlet oxygen General Medicine Virology Oxygen Blood chemistry Cell culture HIV-1 |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0031-8655 |
| Popis: | A number of carboxylic acid derivatives of the photoactive terthiophene, alpha-terthienyl, were found to possess impressive UVA-dependent activity against the human immunodeficiency virus, HIV-1; but only when assayed in the absence of serum, indicating that the latter contained interfering components. Good antiviral activity required a high rate of singlet oxygen production, in accordance with previous observations on thiophenes. |
| Databáze: | OpenAIRE |
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