Glucose, insulin, and somatostatin infusion for the determination of insulin sensitivity in vivo
| Autor: | H. Hidaka, Hiroshi Abe, Y. Harano, S. Ohgaku, K. Kawagoe, S. Motoi, Yukio Shigeta, K. Takatsuki, M. Haneda |
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| Rok vydání: | 1978 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Propranolol Glucagon Endocrinology Insulin resistance Internal medicine Diet Diabetic Diabetes Mellitus medicine Humans Insulin Obesity business.industry Middle Aged medicine.disease Insulin oscillation Glucose Sulfonylurea Compounds Epinephrine Somatostatin Insulin Resistance business Hyperinsulinism hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Metabolism. 27:1449-1452 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(78)90091-4 |
| Popis: | Shen et al.1 and Reaven et al.2 have recently reported increased insulin resistance in adult-onset type diabetes based on the steady state plasma glucose (SSPG) method. In this method, epinephrine and propranolol were used to suppress endogenous insulin secretion. Epinephrine and propranolol themselves elevate SSPG levels.3 Also, plasma levels of growth hormone (HGH) and glucagon may not be suppressed under these conditions, since paradoxical rises or less suppressibility of HGH4 and glucagon5 following glucose loads have been reported in diabetic subjects. We have therefore used somatostatin, which has been shown to have no direct effect on glucose and lipid metabolism,6 to suppress endogenous secretion of insulin, glucagon, and HGH. Using the newly revised method, we have assessed insulin sensitivity in diabetics treated with diet alone, sulfonylureas, or insulin, and in obese nondiabetic subjects with hyperinsulinism. |
| Databáze: | OpenAIRE |
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