New insights into the biotransformation and pharmacokinetics of oxaliplatin
| Autor: | Elin Jerremalm, Inger Wallin, Hans Ehrsson |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Bioanalysis
Molecular Structure Organoplatinum Compounds Metabolic Clearance Rate Chemistry Colorectal cancer Pharmaceutical Science Cancer chemistry.chemical_element Antineoplastic Agents Pharmacology medicine.disease Oxaliplatin Pharmacokinetics Biotransformation In vivo Area Under Curve medicine Humans Colorectal Neoplasms Platinum Half-Life medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 98:3879-3885 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.21732 |
| Popis: | Oxaliplatin is used primarily in the treatment of metastatic colorectal cancer. In this minireview, we discuss potentially important biotransformation pathways in light of its short elimination half-life in vivo. We also highlight new information achieved using a selective analytical technique to measure intact oxaliplatin in pharmacokinetic studies (comprising intravenous, intraperitoneal, and intrahepatic administration) and compare to results obtained by measurements of total platinum. The use of selective analytical techniques is strongly recommended giving kinetic parameters of the parent compound and not only to a complex mixture of platinum containing endogenous compounds. |
| Databáze: | OpenAIRE |
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