Active coping style is associated with natural killer cell cytotoxicity in asymptomatic HIV-1 seropositive homosexual men
| Autor: | Daniel J. Feaster, Karl Goodkin, Nancy G. Klimas, Marianna K Baum, Emilio Mantero-Atienza, Mary A Fletcher, José Szapocznik, Nancy T. Blaney, Carrie Millon, Carl Eisdorfer |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Coping (psychology) Personality Inventory media_common.quotation_subject Health Behavior Natural killer cell Developmental psychology Life Change Events Social support Acquired immunodeficiency syndrome (AIDS) Risk Factors Immunopathology Adaptation Psychological HIV Seropositivity medicine Health Status Indicators Humans Personality Longitudinal Studies Life Style media_common Stressor Sick Role Social Support Homosexuality medicine.disease Killer Cells Natural Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure HIV-1 Psychology Psychosocial |
| Zdroj: | Journal of Psychosomatic Research. 36:635-650 |
| ISSN: | 0022-3999 |
| DOI: | 10.1016/0022-3999(92)90053-5 |
| Popis: | The aim of this study was to examine the hypothesis that a psychosocial model was associated with natural killer cell cytotoxicity (NKCC) in HIV-1 infection. A sample of 62 HIV-1 seropositive homosexual men at CDC stages II and III were given a psychosocial battery assessing life stressors, social support, and coping style. A regression model quantifying these variables along with control variables for alcohol use, substance use and nutritional status was estimated. Active coping style was directly and positively associated with NKCC, and trends toward a negative relationship of life stressors and a buffering effect of social support on lifes stressors were also observed. The results suggest that (1) control variables should be included with psychosocial models and that (2) psychosocial factors, especially active coping, may have a deterrent effect on loss of NK cell function. Active coping style may merit a specific focus in future research of life stressors and the immune system. |
| Databáze: | OpenAIRE |
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