Effect of Cell Therapy on Recovery of Cognitive Functions in Rats during the Delayed Period after Brain Injury
| Autor: | A. G. Konoplyannikov, G. N. Soushkevitch, L. P. Javoronkov, L. N. Pavlova, J. B. Semenova, T. A. Chernyshova, O. V. Karaseva, T. F. Ivanova, O. A. Konoplyannikova, M. V. Marey, Gennady T. Sukhikh, Kolganova Oi, V. V. Yujakov, L. M. Roshal, A. S. Shevchuk, A. F. Tzyb, L. N. Bandurko |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Fetus Pathology medicine.medical_specialty Cell Transplantation business.industry Mesenchymal stem cell Physiology General Medicine General Biochemistry Genetics and Molecular Biology Neural stem cell Rats Transplantation Cell therapy Cognition Brain Injuries Animals Medicine Rats Wistar Stem cell business Adult stem cell Stem cell transplantation for articular cartilage repair |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 148:140-147 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-009-0642-8 |
| Popis: | We studied the effect of systemic transplantation of human stem cells from various tissues on cognitive functions of the brain in rats during the delayed period after experimental brain injury. Stem cells were shown to increase the efficacy of medical treatment with metabolic and symptomatic drugs for recovery of cognitive functions. They accelerated the formation of the conditioned defense response. Fetal neural stem cells had a stronger effect on some parameters of cognitive function 2 months after brain injury. The efficacy of bone marrow mesenchymal stem cells from adult humans or fetuses was higher 3 months after brain injury. |
| Databáze: | OpenAIRE |
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