Pan-Gastrointestinal Tract Mucosal Pathologies in Patients with Celiac Disease with the Demonstration of IgA Anti-Transglutaminase Mucosal Deposits: A Case–Control Study

Autor: Vineet Ahuja, Mahendra Singh Rajput, Ashish Agarwal, Vikas Banyal, Rimlee Dutta, Ashish Upadhay, Madhu Rajeshwari, Govind K. Makharia, Ashish Chauhan, Alka Singh, Prasenjit Das
Rok vydání: 2021
Předmět:
Zdroj: Digestive Diseases and Sciences. 67:3649-3661
ISSN: 1573-2568
0163-2116
DOI: 10.1007/s10620-021-07246-1
Popis: While celiac disease (CeD) is considered to affect primarily the small intestine, pathological changes in other parts of the gastrointestinal tract (GIT) are also known to occur. IgA anti-tissue transglutaminase-2 antibody (anti-TG2 Ab) deposits at the site of involvement is one of the methods to establish CeD-related tissue pathology. To explore the utility of IgA anti-TG2 Ab deposits in pan-gastrointestinal mucosal biopsies as evidence of CeD-related pathologies. Forty-two treatment-naive patients with CeD and 45 patients with irritable bowel syndrome were included as cases and controls, respectively. Mucosal biopsies were collected from the esophagus, stomach, duodenum, and rectosigmoid regions at baseline from cases and controls, and additionally after 6-months of gluten-free diet in cases. All biopsies were evaluated for histological changes and subjected to dual-color immunohistochemical staining for identifying IgA anti-TG2 Ab deposits. Significantly higher number of patients with CeD had lymphocytic esophagitis (9.7% vs. 0%, P = 0.05), lymphocytic gastritis (35% vs. 8.8%, P
Databáze: OpenAIRE
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