Ayurvedic Herbal Preparation Supplementation Does Not Improve Metabolic Health in Impaired Glucose Tolerance Subjects; Observations from a Randomised Placebo Controlled Trial
| Autor: | Diederik Esser, Ron Wehrens, Lydia A. Afman, Jos van der Stappen, Ingrid M. van der Meer, Ric C. H. de Vos, Juri C. Matualatupauw |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_treatment Placebo-controlled study Gene Expression Type 2 diabetes Pharmacology Wiskundige en Statistische Methoden - Biometris Placebos Impaired glucose tolerance Voeding Metabolisme en Genomica 0302 clinical medicine Insulin Medicine Glucose homeostasis Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test Ayurvedic herbal Middle Aged Metabolism and Genomics Cholesterol Health & Consumer Research Biometris Postprandial Metabolisme en Genomica 030220 oncology & carcinogenesis BIOS Applied Metabolic Systems Bioscience Female Nutrition Metabolism and Genomics Type 2-diabetes lcsh:Nutrition. Foods and food supply Adipose tissue lcsh:TX341-641 Placebo Article 03 medical and health sciences Double-Blind Method Voeding Glucose Intolerance Humans Mathematical and Statistical Methods - Biometris Triglycerides Aged Nutrition VLAG Food Health & Consumer Research Glycated Hemoglobin business.industry Overweight medicine.disease Medicine Ayurvedic 030104 developmental biology Diabetes Mellitus Type 2 Whole genome gene expression Food Plant Preparations business Phytotherapy Food Science |
| Zdroj: | Nutrients, 13 Nutrients 13 (2021) Nutrients, Vol 13, Iss 260, p 260 (2021) Nutrients |
| ISSN: | 2072-6643 |
| Popis: | The increased usage of alternative Ayurvedic treatments as potential health-beneficial therapies emphasizes the importance of studying its efficacy in sound placebo-controlled intervention trials. An example of such a traditional Ayurvedic herbal preparation is Mohana Choorna, a mixture composed of 20 different herbs and used to prevent and treat type 2-diabetes (T2D). We studied the efficacy of “Mohana Choorna” on T2D-related parameters in subjects with impaired glucose tolerance. In a double blind, placebo-controlled cross-over trial, 19 overweight (BMI > 27 kg/m2) subjects aged 50–70 years with an impaired glucose tolerance received two four-week interventions, i.e., herbal or placebo with a four-week wash-out between interventions. HbA1c, glucose, insulin, triglycerides, cholesterol, blood pressure and augmentation index were measured before and after both interventions at fasting and during a glucose tolerance test. After both interventions, urine was collected to measure treatment exposure using LCMS-based metabolomics and whole genome gene-expression in adipose tissue of 13 subjects. The herbal intervention did not affect plasma glucose triglycerides, cholesterol, blood pressure or the augmentation index but showed a trend towards an increased insulin, HOMA-IR and postprandial insulin levels (p = 0.054, p = 0.056 and p = 0.095 respectively). An increase in expression of inflammation-related gene sets in adipose tissue was observed after the herbal intervention compared to placebo. Urine metabolomic analysis did not reveal a correlation of the presence of specific plant metabolites with “health markers”. Our findings suggest that there is no substantiating evidence to claim that four weeks’ use of the Ayurvedic herbal supplement Mohana Choorna beneficially affects glucose homeostasis. |
| Databáze: | OpenAIRE |
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