Is focal segmental glomerulosclerosis really focal? Distribution of lesions in adults and children
| Autor: | Agnes B. Fogo, Alan D. Glick, Robert G. Horn, Sarah L. Horn |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Kidney Immunofluorescence urologic and male genital diseases Pathogenesis chemistry.chemical_compound Focal segmental glomerulosclerosis medicine Humans In patient Child Creatinine Sclerosis medicine.diagnostic_test Glomerulosclerosis Focal Segmental business.industry Glomerulosclerosis Glomerulonephritis medicine.disease chemistry Nephrology Kidney Failure Chronic Female business Nephrotic syndrome Follow-Up Studies |
| Zdroj: | Kidney International. 47(6):1690-1696 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1995.234 |
| Popis: | Is focal segmental glomerulosclerosis really focal? Distribution of lesions in adults and children. The distribution of lesions of glomerulosclerosis, whether focal or diffuse, has important implications for pathogenesis and potential therapeutic response. Determination of focal or diffuse nature of lesions from a single section, may, however, be misleading. We therefore evaluated the distribution of segmental glomerulosclerosis in patients with nephrotic syndrome and idiopathic focal segmental glomerulosclerosis (FSGS) by three-dimensional analysis. From our files, we identified all such biopsies with a diagnosis established by immunofluorescence, electron microscopy, and light microscopy that had >10 glomeruli and serum creatinine |
| Databáze: | OpenAIRE |
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