Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis

Autor: Benjamin Raud, Chloé Gay, Candy Guiguet-Auclair, Armand Bonnin, Laurent Gerbaud, Bruno Pereira, Martine Duclos, Yves Boirie, Emmanuel Coudeyre
Přispěvatelé: Unité de Nutrition Humaine - Clermont Auvergne (UNH), Université Clermont Auvergne (UCA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Clermont Auvergne (UCA), Médecine physique et de réadaptation, Centre Hospitalier Universitaire de Clermont-Ferrand, Santé publique, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pascal, Centre National de la Recherche Scientifique (CNRS), SIGMA Clermont, Délégation Recherche Clinique et Innovation, Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Innovatherm cluster Clermont-Ferrand Communaute Region Auvergne-Rhone-Alpes, ProdInra, Archive Ouverte
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
WOMAC
Epidemiology
Cross-sectional study
Visual analogue scale
lcsh:Medicine
Osteoarthritis
Overweight
Article
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Quality of life
Risk Factors
Surveys and Questionnaires
Internal medicine
Humans
Medicine
Obesity
lcsh:Science
Exercise
Aged
030203 arthritis & rheumatology
2. Zero hunger
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Multidisciplinary
business.industry
lcsh:R
Middle Aged
Osteoarthritis
Knee
medicine.disease
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
Cross-Sectional Studies
Cartilage
Disease Progression
Quality of Life
lcsh:Q
Female
France
medicine.symptom
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Body mass index
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
030217 neurology & neurosurgery
Zdroj: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-60587-1⟩
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-60587-1⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
ISSN: 2045-2322
DOI: 10.1038/s41598-020-60587-1
Popis: Obesity is one of the most important risk factors of knee osteoarthritis (KOA), but its impact on clinical and functional consequences is less clear. The main objective of this cross-sectional study was to describe the relation between body mass index (BMI) and clinical expression of KOA. Participants with BMI ≥ 25 kg/m2 and KOA completed anonymous self-administered questionnaires. They were classified according to BMI in three groups: overweight (BMI 25–30 kg/m2), stage I obesity (BMI 30–35 kg/m2) and stage II/III obesity (BMI ≥ 35 kg/m2). The groups were compared in terms of pain, physical disability, level of physical activity (PA) and fears and beliefs concerning KOA. Among the 391 individuals included, 57.0% were overweight, 28.4% had stage I obesity and 14.6% had stage II/III obesity. Mean pain score on a 10-point visual analog scale was 4.3 (SD 2.4), 5.0 (SD 2.6) and 5.2 (SD 2.3) with overweight, stage I and stage II/III obesity, respectively (p = 0.0367). The mean WOMAC function score (out of 100) was 36.2 (SD 20.1), 39.5 (SD 21.4) and 45.6 (SD 18.4), respectively (p = 0.0409). The Knee Osteoarthritis Fears and Beliefs Questionnaire total score (KOFBEQ), daily activity score and physician score significantly differed among BMI groups (p = 0.0204, p = 0.0389 and p = 0.0413, respectively), and the PA level significantly differed (p = 0.0219). We found a dose–response relation between BMI and the clinical consequences of KOA. Strategies to treat KOA should differ by obesity severity. High PA level was associated with low BMI and contributes to preventing the clinical consequences of KOA.
Databáze: OpenAIRE
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