Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth
| Autor: | Halimah Abdul-Waalee, Lisa Bonar, Mary L. Phillips, Genna Bebko, Kelly Monk, Danella Hafeman, Jay C. Fournier, Cecile D. Ladouceur, Dara Sakolsky, Tina R. Goldstein, Amelia Versace, Boris Birmaher, Michele A. Bertocci, Renata Rozovsky |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bipolar Disorder Adolescent Offspring Uncinate fasciculus Prefrontal cortex Article White matter 03 medical and health sciences 0302 clinical medicine Internal medicine Fractional anisotropy Humans Medicine Bipolar disorder Pharmacology Psychopathology business.industry Emotional regulation medicine.disease White Matter Pathophysiology 030227 psychiatry Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure Anisotropy business 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychopharmacology |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/s41386-021-01088-1 |
| Popis: | Bipolar disorder (BD) is highly heritable. Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD participants with a first-degree relative with BD, 25 offspring of BD parents, 27 offspring of comparison parents with non-BD psychiatric disorders, and 32 healthy offspring of healthy parents. In at-risk groups, 23 had non-BD diagnoses and 29, no Axis-I diagnoses(healthy). Five at-risk offspring who developed BD post scan(Converters) were included. Diffusion imaging(dMRI) analysis with tract segmentation identified between-group differences in the microstructure of prefrontal tracts supporting emotional regulation relevant to BD: forceps minor, anterior thalamic radiation(ATR), cingulum bundle(CB), and uncinate fasciculus(UF). BD participants showed lower fractional anisotropy (FA) in the right CB (anterior portion) than other groups (q q qs qs qs |
| Databáze: | OpenAIRE |
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