Effect of Pygeum africanum tadenan on micturition and prostate growth of the rat secondary to coadministered treatment and post-treatment with dihydrotestosterone
| Autor: | Osamu Yamaguchi, Yosh Yoshimura, Francois Bellamy, Christos E. Constantinou |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty food.ingredient medicine.drug_class Urology media_common.quotation_subject Urinary Bladder Urination Rats Sprague-Dawley food Prostate Internal medicine Animals Medicine media_common Plant Extracts business.industry Dihydrotestosterone Pygeum africanum Organ Size Androgen Growth Inhibitors Rats Urodynamics Prunus africana Endocrinology medicine.anatomical_structure Peanut oil Sesame oil Fatty Alcohols Post treatment business medicine.drug |
| Zdroj: | Urology. 61:474-478 |
| ISSN: | 0090-4295 |
| DOI: | 10.1016/s0090-4295(02)02155-6 |
| Popis: | Objectives Pretreatment with oral tadenan (TAD) has been shown to possess a protective effect on bladder dysfunction-induced obstruction. We evaluated the functional influence of cotreatment and post-treatment with oral TAD on the frequency/volume characteristics of micturition of conscious rats stimulated with exogenous dihydrotestosterone (DHT) to induce experimental prostate growth. Methods Studies were done on 36 adult Sprague-Dawley male rats, treated daily for 6 weeks and grouped as follows: group 1, sesame oil during weeks 1 and 2, peanut oil during weeks 3 to 6; group 2, DHT (1.25 mg/kg subcutaneously) dissolved in sesame oil as vehicle during weeks 1 and 2 and peanut oil during weeks 3 to 6; group 3, DHT (1.25 mg/kg subcutaneously) dissolved in sesame oil as vehicle and TAD (100 mg/kg orally) in peanut oil during weeks 1 and 2 and TAD during weeks 3 to 6; and group 4, DHT in sesame oil during weeks 1 and 2 and TAD in peanut oil during weeks 3 to 6. The characteristics of frequency/volume were monitored biweekly and at the sixth week. Results Controls showed no significant changes from baseline values in volume or frequency during the entire study period. DHT treatment produced a significant increase in frequency (1.9 ± 0.3 to 3.0 ± 0.4/hr) and a significant decrease in volume (1.8 ± 0.3 to 1.2 ± 0.1 mL). In groups 3 and 4, no significant changes occurred in frequency or volume. By the sixth week of observation, the effects of DHT treatment decreased to control values in all groups. A significant increase in prostatic weight (1191 ± 11 to 1434 ± 17 mg/kg) was produced by DHT treatment and TAD cotreatment suppressed growth to 1390 ± 8.4 mg/kg. Conclusions TAD cotreatment or post-treatment suppressed the effects of DHT on micturition, and TAD cotreatment regressed a developing increase in prostatic weight. Post-treatment TAD administration did not reduce already established growth. |
| Databáze: | OpenAIRE |
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