Erythrocyte hyperaggregation in obesity: determining factors and weight loss influence
| Autor: | Maria-Luisa Santaolaria, Eva Solá, Francisco España, Amparo Estellés, Dolores Corella, Antonio Hernández-Mijares, Amparo Vayá |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Blood Glucose Erythrocyte Aggregation Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Cardiovascular risk factors Medicine (miscellaneous) Fibrinogen Erythrocyte aggregation Statistics Nonparametric Endocrinology Insulin resistance Weight loss Internal medicine Weight Loss medicine Humans Insulin In patient Obesity Triglycerides Nutrition and Dietetics business.industry Anthropometry Middle Aged medicine.disease C-Reactive Protein Cholesterol Female medicine.symptom Insulin Resistance business medicine.drug |
| Zdroj: | Obesity r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 1930-7381 |
| Popis: | Objective: To compare erythrocyte aggregation (EA) in patients with severe obesity without other cardiovascular risk factors with a control group, using the Myrenne and the Sefam aggregometers, and to evaluate the effect of weight loss on this parameter. Research Methods and Procedures: This was a longitudinal, clinical intervention study of a very low-calorie diet for 4 weeks followed by a low-calorie diet for 2 months. In 67 severely obese patients, an anthropometric and analytical evaluation [plasmatic lipids, fibrinogen (Fbg), and EA] was performed at baseline and 3 months after diet. The same determinations were performed in 67 normal-weight volunteers. EA was measured with the Myrenne MA 1 , which determines EA at stasis (EA 0 ) and at a low shear of 3 seconds -1 (EA 1 ), and the Sefam aggregometer, which determines aggregation index at 10 seconds -1 (IA 10 ), aggregation time (Ta), and disaggregation threshold (yD). Insulin resistance (IR) was calculated by homeostasis model assessment. Results: Obese patients showed higher Fbg levels, EA 0 , EA 1 ,IA 10 , and γD values, and lower Ta values. Differences between obese patients and control group for EA 0 , EA 1 , Ta, IA 10 , and γD disappeared after adjusting for BMI or for homeostasis model assessment but were maintained after adjusting for Fbg or low-density lipoprotein-cholesterol. Obese patients with IR showed higher EA 0 and EA 1 values. After weight loss, EA 1 showed a significant improvement. Discussion: Obese patients show increased EA. Erythrocyte hyperaggregation does not seem to be related to a high Fbg level or to an abnormal lipid profile but to IR. Hyperagreggation improves after weight loss. |
| Databáze: | OpenAIRE |
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