Hepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review
| Autor: | Brian Egan, Niamh Nolan, John Hegarty, Shahzad Sarwar, Jeremy P. Dwyer |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Necrosis medicine.medical_treatment Iron Liver transplantation Phlebotomy medicine Homeostasis Humans Hemochromatosis Protein Hemochromatosis Hepatology medicine.diagnostic_test business.industry Biopsy Needle Histocompatibility Antigens Class I Membrane Proteins Middle Aged medicine.disease Small intestine Tissue Donors Liver Transplantation Transplantation medicine.anatomical_structure Amino Acid Substitution Liver biopsy Ferritins Female medicine.symptom Pancreas business |
| Zdroj: | Liver international : official journal of the International Association for the Study of the Liver. 31(10) |
| ISSN: | 1478-3231 |
| Popis: | Hereditary haemochromatosis is a common genetic disease associated with progressive iron overload and parenchymal organ damage including liver, pancreas and heart. We report a case of inadvertent transplantation of a liver from a haemochromatosis donor to a 56-year-old Asian female. Progressive iron overload occurred over a 2 year follow up as assessed by liver biopsy and iron studies in the absence of a secondary cause of iron overload, supporting a primary role of liver rather than small intestine in the regulation of iron homeostasis in hereditary haemochromatosis. |
| Databáze: | OpenAIRE |
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