Efficacy of ivermectin versus dual infections of Haemonchus contortus and Heligmosomoides polygyrus in the mouse
| Autor: | D. A. Ostlind, W. G. Mickle, S. Cifelli, Scott K. Smith, D. V. Ewanciw |
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| Rok vydání: | 2012 |
| Předmět: |
Test group
Sensitivity and Specificity Microbiology Mice Ivermectin parasitic diseases medicine Animals Ecology Evolution Behavior and Systematics Strongylida Infections Anthelmintics Nematospiroides dubius biology Stomach biology.organism_classification Animal Feed Disease Models Animal medicine.anatomical_structure Parasitology Female Haemonchus Heligmosomoides polygyrus Haemonchiasis medicine.drug Haemonchus contortus |
| Zdroj: | The Journal of parasitology. 99(1) |
| ISSN: | 1937-2345 |
| Popis: | This report describes a novel assay for the detection of gastrointestinal anthelmintics using mice infected with Haemonchus contortus and adapted to the 1 animal/test group protocol. Mice infected with both H. contortus and Heligmosomoides polygyrus were fed ivermectin-medicated diets for 6 days. A dietary level of 0.09375 ppm was 98.1% effective against the 0- to 6-day-old abomasal stomach worm of sheep, whereas a level of 0.75 ppm reduced the 3- to 9-day-old H. polygyrus worm burden by 94.0%. H. contortus was approximately 8-fold more sensitive to ivermectin than was H. polygyrus in this model. The sensitivity of this assay rivals that of the gerbil-Trichostrongylus colubriformis model while utilizing a more economical host. |
| Databáze: | OpenAIRE |
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