Long non-coding RNA: Functional agent for disease traits
| Autor: | Manika Pal Bhadra, Utpal Bhadra, Nirav Thakkar, Sriyans Jain, Jagamohan Chhatai |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging Cellular differentiation Apoptosis Review Disease Biology Autoimmune Diseases Mice 03 medical and health sciences Endocrine Glands Neoplasms Gene expression Animals Humans Epigenetics Molecular Biology Genetics Regulation of gene expression Immunity Cell Differentiation Translation (biology) Cell Biology Long non-coding RNA Rats 030104 developmental biology Gene Expression Regulation Cardiovascular Diseases RNA Long Noncoding Human genome Nervous System Diseases Biomarkers |
| Zdroj: | RNA Biology. 14:522-535 |
| ISSN: | 1555-8584 1547-6286 |
| Popis: | In recent years, long non-coding RNAs (lncRNAs) have attracted the attention of researchers with their involvement in all facets of life. LncRNAs are transcripts of more than 200 nucleotides which lack defined protein coding potential. Although they do not code for proteins, a large number of them are involved in regulating gene expression and translation. The presence of numerous lncRNAs in the human genome has prompted us to investigate the contribution of these molecules to human biology and medicine. In this review, we present the potential role of lncRNAs interlinked to different human diseases and genetic disorders. We also describe their role in cellular differentiation and aging and discuss their potential importance as biomarkers and as therapeutic agents. |
| Databáze: | OpenAIRE |
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