Subacute nephrotoxicity of germanium dioxide in the experimental animal
| Autor: | Shinichiro Osato, Tetsuo Komota, Nobuaki Oochi, Kaoru Onoyama, Masatoshi Fujishima, Seiya Okuda, Shigemi Kiyama, Toru Sanai |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Pathology Metabolic Clearance Rate Toxicology Nephrotoxicity Excretion Hypoproteinemia chemistry.chemical_compound Eating Oral administration Internal medicine medicine Animals Kidney Tubules Distal Pharmacology Kidney Creatinine Chemistry Germanium Body Weight Albumin Organ Size Acute Kidney Injury Kidney Tubular Necrosis Acute medicine.disease Rats Microscopy Electron Endocrinology medicine.anatomical_structure Toxicity Mitochondrial Swelling |
| Zdroj: | Toxicology and applied pharmacology. 103(2) |
| ISSN: | 0041-008X |
| Popis: | Germanium (Ge; atomic number 32, atomic weight 72.6) belongs to IVb group of the Periodic Table and is found as a trace metal in soil, rocks, plants, and animals. It is widely used in industry because of its semiconductive nature. Some biological activities have been shown in Ge derivatives. Recently, patients with persistent renal damage after chronic ingestion of germanium dioxide (GeO2)-containing compounds have been reported in Japan. This study aimed to investigate subacute nephrotoxicity of GeO2 in Lewis male rats. The rats were treated orally with GeO2 for 13 weeks (GeO2 group) and were compared with those treated with GeO2 for only the first 4 weeks (GeO2-4-week group) and with untreated controls. Renal dysfunction was demonstrated by the increased serum creatinine, BUN, and serum phosphate and decreased creatinine clearance. Liver dysfunction was observed as demonstrated by the increased GOT and GPT, and hypoproteinemia by the decreased total protein and albumin in the GeO2 group. However, daily urinary protein excretion or urinalysis did not differ among the groups. Kidney weight and Ge content of tissues were significantly elevated in the GeO2 group. With the light microscope, vacuoles and the depositions of PAS-stained particles, which correspond to electron-microscopic dense granules in the swollen mitochondria, were predominantly observed in distal tubular epithelium in the GeO2 group. Even in the GeO2-4-week group of rats, serum creatinine was increased and the abovementioned histological abnormalities were observed, but were less intense. |
| Databáze: | OpenAIRE |
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