Living network meta-analysis was feasible when considering the pace of evidence generation
| Autor: | Ludovic Trinquart, Nassima Attiche, Perrine Créquit, Philippe Ravaud, Alexandre Vivot, Tania Martin-Montoya |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Evidence-Based Medicine Epidemiology business.industry Workload 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic Interquartile range Meta-analysis Emergency medicine Medicine Humans 030212 general & internal medicine business 030217 neurology & neurosurgery Evidence synthesis Pace Randomized Controlled Trials as Topic Systematic Reviews as Topic |
| Zdroj: | Journal of clinical epidemiology. 108 |
| ISSN: | 1878-5921 |
| Popis: | Objectives The aim of the study was to assess the feasibility of living network meta-analysis (NMA) taking into account the pace of evidence generation across different medical areas. Study Design and Setting We performed a systematic review to identify published NMAs. For each NMA, we calculated the cumulative number of new trials. To assess the feasibility of living NMA, we considered different update frequencies (4, 6, and 12 months), then evaluated the number of new trials to be included at each update in the NMA and the workload percentage for an update relative to the initial NMA. Results We identified 77 NMAs covering 17 different medical areas; 60 (78%) had fewer than four new trials included per year, on average, and 5 (7%) had more than seven trials. With an update frequency of 4, 6, and 12 months, the median number of new trials to be included in the NMA was 0 (interquartile range, 0–1), 1 (0–2), and 2 (1–4), respectively, with mean of 4%, 5%, and 11% workload per update, respectively. Conclusion The workload associated with updating a living NMA represents about one-tenth of the initial workload; therefore, living NMA is manageable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect