In Vitro Activity of Tedizolid Against Gram-Positive Bacteria in Patients With Skin and Skin Structure Infections and Hospital-Acquired Pneumonia: A Korean Multicenter Study
Autor: | Kyungwon Lee, Yangsoon Lee, Sung Hak Choi, Dongeun Yong, Sung Kuk Hong, Weonbin Im |
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Rok vydání: | 2015 |
Předmět: |
Methicillin-Resistant Staphylococcus aureus
Impetigo Clinical Biochemistry Microbial Sensitivity Tests Brief Communication medicine.disease_cause Hospital-acquired pneumonia Skin Diseases Erysipelas Microbiology Minimum inhibitory concentration chemistry.chemical_compound Asian People Republic of Korea Humans Medicine Oxazoles Gram-Positive Bacterial Infections Skin business.industry Biochemistry (medical) Linezolid Soft tissue Pneumonia General Medicine Gram-positive bacteria medicine.disease Methicillin-resistant Staphylococcus aureus Hospitals Organophosphates Anti-Bacterial Agents Clinical Microbiology chemistry Staphylococcus aureus Tedizolid Infection business |
Zdroj: | Annals of Laboratory Medicine |
ISSN: | 2234-3814 2234-3806 |
Popis: | We compared the activities of tedizolid to those of linezolid and other commonly used antimicrobial agents against gram-positive cocci recovered from patients with skin and skin structure infections (SSSIs) and hospital-acquired pneumonia (HAP) in Korean hospitals. Gram-positive isolates were collected from 356 patients with SSSIs and 144 patients with HAP at eight hospitals in Korea from 2011 to 2014. SSSIs included impetigo, cellulitis, erysipelas, furuncles, abscesses, and infected burns. Antimicrobial susceptibility was tested by using the CLSI agar dilution method. All of the gram-positive isolates were inhibited by ≤1 μg/mL tedizolid. The minimum inhibitory concentration [MIC]₉₀ of tedizolid was 0.5 μg/mL for methicillin-resistant Staphylococcus aureus, which was 4-fold lower than that of linezolid. Tedizolid may become a useful option for the treatment of SSSIs and HAP caused by gram-positive bacteria. |
Databáze: | OpenAIRE |
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