Identification of 7-Deoxy-desulfo-argino-cylindrospermopsin, the Missing Piece in Cylindrospermopsin Biosynthesis

Autor:	Annick Méjean, Olivier Lequin, Olivier Ploux
Rok vydání:	2022
Předmět:	Zinc Colloid and Surface Chemistry Cyanobacteria Toxins Bacterial Toxins General Chemistry Arginine Cyanobacteria Uracil Polyketide Synthases Biochemistry Catalysis
Zdroj:	Journal of the American Chemical Society. 144:14627-14637
ISSN:	1520-5126 0002-7863
Popis:	Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo-argino-cylindrospermopsin in several cylindrospermopsin-producing cyanobacteria using mass spectrometry experiments. We have purified this new metabolite and established its structure by 1D and 2D NMR spectroscopy using scalar-based
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b90ae1b2d7097f6f6a778cb84667d1 https://doi.org/10.1021/jacs.2c03932 Zobrazit plný text záznamu