Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate

Autor: Ting-Cheng Tang, Sydney Peng, Shuian-Yin Lin, Pa Fan Hsiao, Hsieh-Chih Tsai
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Materials science
Skin Absorption
amphiphilic copolymer
Biophysics
Pharmaceutical Science
Nanoparticle
Bioengineering
Nanotechnology
02 engineering and technology
skin penetration
Administration
Cutaneous

010402 general chemistry
01 natural sciences
Polyethylene Glycols
Rats
Sprague-Dawley

Biomaterials
chemistry.chemical_compound
Drug Delivery Systems
oleylamine
Microscopy
Electron
Transmission

Oleylamine
International Journal of Nanomedicine
Drug Discovery
PEG ratio
Zeta potential
Animals
Amines
Original Research
Transdermal
poly(ethylene glycol)
Organic Chemistry
technology
industry
and agriculture

General Medicine
021001 nanoscience & nanotechnology
0104 chemical sciences
Microscopy
Fluorescence

Chemical engineering
chemistry
Colloidal gold
Nanoparticles
Surface modification
Spectrophotometry
Ultraviolet

Gold
0210 nano-technology
Ethylene glycol
gold nanoparticle
Zdroj: International Journal of Nanomedicine
ISSN: 1178-2013
Popis: Pa Fan Hsiao,1–3 Sydney Peng,4 Ting-Cheng Tang,4 Shuian-Yin Lin,5 Hsieh-Chih Tsai4 1Department of Dermatology, Mackay Memorial Hospital, 2Mackay Medicine, Nursing and Management College, 3Mackay Medical College, New Taipei City, 4Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 5National Applied Research Laboratories, Instrument Technology Research Center, Hsinchu,Taiwan Abstract: In this study, we investigated the effect of (ethylene glycol) (PEG) andPEG–oleylamine (OAm) functionalization on the skin permeation property of gold nanoparticles (GNS) in vivo. Chemisorption of polymers onto GNS was verified by a red shift in the ultraviolet–visible spectrum as well as by a change in the nanoparticle surface charge. The physicochemical properties of pristine and functionalized nanoparticles were analyzed by ultraviolet–visible spectroscopy, zeta potential analyzer, and transmission electron microscopy. Transmission electron microscopy revealed that the interparticle distance between nanoparticles increased after GNS functionalization. Comparing the skin permeation profile of pristine and functionalized GNS, the follicular deposition of GNS increased twofold after PEG–OAm functionalization. Moreover, PEG- and PEG–OAm-functionalized nanoparticles were able to overcome the skin barrier and deposit in the deeper subcutaneous adipose tissue. These findings demonstrate the potential of PEG- and PEG–OAm-functionalized GNS in serving a multitude of applications in transdermal pharmaceuticals. Keywords: skin penetration, amphiphilic copolymer, gold nanoparticle, oleylamine, poly(ethylene glycol)
Databáze: OpenAIRE
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