Immunoexpression of LGR4 and Β-Catenin in Gastric Cancer and Normal Gastric Mucosa
| Autor: | Paulo Goberlânio de Barros Silva, Amanda Cristina Crispim Farias, Paulo Roberto de Almeida, Bruno Jucá Rodrigues, Camila de Carvalho Juanes, Susana Moreira de Souza, Kélvia Miranda Sá, Caroline Cavalcante Campelo, Adriana Estela Flores Valiente |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Adenocarcinoma Receptors G-Protein-Coupled 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine LGR4 Stomach Neoplasms Biomarkers Tumor Medicine Humans Lymph node beta Catenin Tissue microarray business.industry Stomach Cancer General Medicine Middle Aged β-catenin medicine.disease Prognosis Survival Rate stem cell 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies Gastric Mucosa 030220 oncology & carcinogenesis Catenin Case-Control Studies Lymphatic Metastasis Cancer cell Immunohistochemistry Female business Gastric cancer Follow-Up Studies Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Background: We evaluated the immunoexpression of LGR4 and β-catenin in primary gastric carcinomas, lymph node metastases and histologically normal gastric mucosa in the surgical margins of gastric primary tumours. Methods: We performed a cross-sectional, observational study, based on 75 gastric carcinoma specimens from gastrectomies conducted at the hospital of the Federal University of Ceara, Brazil. The samples were analysed by tissue microarray and immunohistochemistry. Chi-square, Fisher’s exact test and Pearson’s linear regression were used in this study. Results: LGR4 expression was greater in the histologically normal gastric mucosa (basal third of the epithelial thickness) of the tumour surgical resection margin than in the cases of primary carcinomas (P |
| Databáze: | OpenAIRE |
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