Impact of Acute Coronary Syndromes on Two-Year Clinical Outcomes in Patients With Unprotected Left Main Coronary Artery Stenosis Treated With Drug-Eluting Stents
| Autor: | Stefano De Servi, Giuseppe Vecchi, Diego Sangiorgi, Antonio L. Bartorelli, Antonio Marzocchi, Marco De Carlo, Luigi Vignali, Leonardo Bolognese, Giulia Lauria, Alberto Benassi, Massimo Margheri, Imad Sheiban, Giuseppe Sangiorgi, Vincenzo Filippone, Nicoletta Franco, Angelo Ramondo, Massimo Medda, Carlo Briguori, Francesco Di Pede, Tullio Palmerini, Cataldo Palmieri, Corrado Tamburino |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Acute coronary syndrome medicine.medical_treatment Coronary Left Main Coronary Artery Stenosis Cohort Studies Coronary artery disease Left coronary artery Risk Factors medicine.artery Angioplasty Internal medicine 80 and over medicine Humans Myocardial infarction Acute Coronary Syndrome Angioplasty Balloon Coronary Aged Retrospective Studies Aged 80 and over business.industry Unstable angina Coronary Stenosis Drug-Eluting Stents Middle Aged medicine.disease Survival Analysis Treatment Outcome Drug-eluting stent Cardiology Female Balloon Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American Journal of Cardiology. 105:174-178 |
| ISSN: | 0002-9149 |
| Popis: | In this study we investigated the impact of acute coronary syndromes (ACSs) on clinical outcomes in patients with unprotected left main coronary artery (ULMCA) stenosis treated with drug-eluting stents (DESs). In this multicenter, retrospective, observational study we enrolled 1,101 patients with ULMCA stenosis treated with DESs. Six hundred eleven patients presented with ACS and 490 had stable coronary artery disease. ACS was defined as the presence of unstable angina or non-ST-segment elevation myocardial infarction (MI). During 2-year follow-up, the adjusted hazard ratio of cardiac mortality and MI of patients with ACS versus stable patients was 2.42 (95% confidence interval 1.37 to 4.28, p = 0.002). We observed a stepwise risk increase, namely patients with stable coronary disease had the lowest risk, patients with unstable angina an intermediate risk, and patients with non-ST-segment elevation MI the highest risk. The increased risk of cardiac mortality and MI of patients with ACS was concentrated in the first year after DES implantation. In conclusion, patients with ULMCA stenosis and ACS treated with DESs have an increased risk of cardiac mortality and MI during the first year after the intervention compared to stable patients. |
| Databáze: | OpenAIRE |
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