Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study
| Autor: | Cynthia M. Verwer, Frank H. de Jong, Martin van den Berg, Sabina Litens, Natalia Stern, Wout Slob, Josephus G. Vos, Pim E.G. Leonards, Rocío F. Cantón, Ute M.D. Schauer, Helen Håkansson, Hellmuth Lilienthal, Wolfgang Dekant, Aart Verhoef, Theo J. Visser, Aldert H. Piersma, Leo T.M. van der Ven, Ton van de Kuil |
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| Přispěvatelé: | Internal Medicine, Chemistry and Biology |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Thyroid Hormones media_common.quotation_subject Polybrominated Biphenyls Administration Oral Ovary Biology Endocrine Disruptors Toxicology Bone and Bones chemistry.chemical_compound SDG 3 - Good Health and Well-being Internal medicine Toxicity Tests medicine Animals Tissue Distribution Rats Wistar Testosterone media_common Bone Development Dose-Response Relationship Drug Reproduction Body Weight Organ Size Rats Dose–response relationship Endocrinology medicine.anatomical_structure chemistry Endocrine disruptor Toxicity Brominated flame retardant Tetrabromobisphenol A Female |
| Zdroj: | Toxicology, 245(1-2), 76-89. Elsevier Ireland Ltd van der Ven, L T M, van de Kuil, T, Verhoef, A, Verwer, C M, Lilienthal, H, Leonards, P E G, Schauer, U M D, Canton, R F, Litens, S, de Jong, F H, Visser, T J, Dekant, W, Stern, N, Hakansson, H, Slob, W, van den Berg, M, Vos, J G & Piersma, A H 2008, ' Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study ', Toxicology, vol. 245, no. 1-2, pp. 76-89 . https://doi.org/10.1016/j.tox.2007.12.009 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/j.tox.2007.12.009 |
| Popis: | Endocrine effects of the brominated flame retardant tetrabromobisphenol-A (TBBPA) were studied in a one-generation reproduction assay in Wistar rats via repeated dietary exposure, applying eight dose groups at 0-3-10-30-100-300-1000-3000 mg/kg body weight/day (mkd). This design enables dose-response analysis and calculation of benchmark doses (BMDL). This reproduction study was preceded by a 28-day repeat dose subacute toxicity study, at 0-30-100-300 mkd. Major effects in the reproduction study included decreased circulating thyroxine (T4) with BMDLs of 31 (m) and 16 (f) mkd, and increased weight of testis and male pituitary (BMDLs of 0.5 and 0.6 mkd). The hypothyroxinemia correlated to a cluster of developmental parameters including delayed sexual development in females, decreased pup mortality, and effects on brainstem auditory evoked potentials [Lilienthal, H., Verwer, C.M., Van der Ven, L.T.M., Piersma, AM., Vos, J.G., 2008. Neurobehavioral effects of tetrabromobisphenol A (TBBPA) in rats after pre- and postnatal exposure. Toxicology]. A second cluster of parameters in F1 animals was correlated to increased testis weight, and included female gonad weight, endometrium height, CYP19/aromatase activity in the ovary, and plasma testosterone levels in males. These two correlation clusters,suggest a dual action of TBBPA. The only effects in the subacute study were decreased circulating T4 and increased T3 levels in males (BMDLs 48 and 124 mkd), and non-significant trends for these parameters in females, suggesting that the other effects in the reproduction study were induced during development. Combined with data of human exposure to environmental TBBPA, the margin of exposure for highly exposed populations can be calculated at 2.6, and current use of TBBPA may therefore be a matter of concern for human health. (C) 2007 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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