Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment
| Autor: | Francis F. Kirigin, Erica Sodergren, Victoria E. Ruiz, Jennifer Chung, Huilin Li, Cecily M. Barber, Makedonka Mitreva, George M. Weinstock, Yanjiao Zhou, Laura M. Cox, Alexander V. Alekseyenko, Jiho Sohn, Sahar Abubucker, Yael R. Nobel, Martin J. Blaser, Kartik Raju, David S. Goldfarb, Nicholas A. Bokulich, Shingo Yamanishi, Isabel Teitler |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Aging medicine.drug_class Population structure Antibiotics General Physics and Astronomy Biology General Biochemistry Genetics and Molecular Biology Drug Administration Schedule Article Microbiology Transcriptome 03 medical and health sciences Feces Mice medicine Animals Microbiome 030304 developmental biology Bone growth 0303 health sciences Multidisciplinary 030306 microbiology Amoxicillin General Chemistry Early life 3. Good health Anti-Bacterial Agents Mice Inbred C57BL Gene Expression Regulation Liver Metagenomics Drug Therapy Combination Female Tylosin Energy Metabolism medicine.drug |
| Zdroj: | Nature Communications Nature Communications, 6 (1) |
| ISSN: | 2041-1723 |
| Popis: | Mammalian species have co-evolved with intestinal microbial communities that can shape development and adapt to environmental changes, including antibiotic perturbation or nutrient flux. In humans, especially children, microbiota disruption is common, yet the dynamic microbiome recovery from early-life antibiotics is still uncharacterized. Here we use a mouse model mimicking paediatric antibiotic use and find that therapeutic-dose pulsed antibiotic treatment (PAT) with a beta-lactam or macrolide alters both host and microbiota development. Early-life PAT accelerates total mass and bone growth, and causes progressive changes in gut microbiome diversity, population structure and metagenomic content, with microbiome effects dependent on the number of courses and class of antibiotic. Whereas control microbiota rapidly adapts to a change in diet, PAT slows the ecological progression, with delays lasting several months with previous macrolide exposure. This study identifies key markers of disturbance and recovery, which may help provide therapeutic targets for microbiota restoration following antibiotic treatment. The potential recovery of the human gut microbiota after an antibiotic treatment, and its effects on our health, are poorly understood. Here, the authors use a mouse model mimicking paediatric antibiotic use to shed new light into these processes. |
| Databáze: | OpenAIRE |
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