Cytogenetic studies in twelve patients with primary myelofibrosis and myeloid metaplasia
| Autor: | Dray C, Marcel Krulik, Aimery de Gramont, Jacques Debray, Alain A. Audebert, Nicole Smadja, P. Brissaud, A. Sirinelli |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Genetic Markers
Male Cancer Research medicine.medical_specialty Pathology Myeloid Aneuploidy Biology Metaplasia Genetics medicine Humans Myelofibrosis Molecular Biology Aged Chromosome Aberrations Cytogenetics Karyotype Middle Aged medicine.disease Chromosome Banding medicine.anatomical_structure Primary Myelofibrosis Karyotyping Immunology Female Bone marrow medicine.symptom Trisomy |
| Zdroj: | Cancer Genetics and Cytogenetics. 24:151-158 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(87)90092-6 |
| Popis: | Chromosome studies on bone marrow and/or peripheral blood cells without phytohemagglutinin were performed on 12 patients with primary myelofibrosis with myeloid metaplasia (PMMM) between 1980 and 1984. Abnormal clones were found in six patients (50%). In five cases the abnormal clone involved the long arm of chromosome #7, two of which also had partial trisomy of chromosome #1 and trisomy of 9. Additional abnormalities involving chromosomes #3, #5, #11, #13, #15, and #21 were each found once. Review of the literature showed few studies on the cytogenetics of PMMM. No specific chromosomal pattern can be established; however, abnormalities described are nonrandom. |
| Databáze: | OpenAIRE |
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