Effects of gallic acid on delta - aminolevulinic dehydratase activity and in the biochemical, histological and oxidative stress parameters in the liver and kidney of diabetic rats
| Autor: | Thauan Faccin Lopes, Jucimara Baldissareli, Maria Rosa Chitolina Schetinger, Aline da Silva Pereira, Lizielle Souza de Oliveira, Gustavo R. Thomé, Juliana Sorraila de Oliveira, Vera Maria Morsch, Karine Paula Reichert, Cristina da Costa Krewer, Roselia Maria Spanevello |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood Glucose Male medicine.medical_specialty Antioxidant medicine.medical_treatment medicine.disease_cause Kidney Thiobarbituric Acid Reactive Substances Streptozocin Diabetes Mellitus Experimental Lipid peroxidation Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Internal medicine Diabetes mellitus Gallic Acid medicine TBARS Animals Gallic acid Rats Wistar Glutathione Transferase Pharmacology biology Superoxide Dismutase Body Weight Porphobilinogen Synthase General Medicine medicine.disease Catalase Oxidative Stress 030104 developmental biology Endocrinology chemistry Liver Delta-aminolevulinic acid dehydratase biology.protein Hepatocytes Lipid Peroxidation Reactive Oxygen Species Oxidative stress |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 84 |
| ISSN: | 1950-6007 |
| Popis: | Diabetes mellitus (DM) is characterised by hyperglycaemia associated with the increase of oxidative stress. Gallic acid has potent antioxidant properties. The aim of this study was to evaluate the effect of gallic acid on the biochemical, histological and oxidative stress parameters in the liver and kidney of diabetic rats. Male rats were divided in groups: control, gallic acid, diabetic and diabetic plus gallic acid. DM was induced in the animals by intraperitoneal injection of streptozotocin (65mg/kg). Gallic acid (30mg/kg) was administered orally for 21days. Our results showed an increase in reactive species levels and lipid peroxidation, and a decrease in activity of the enzymes superoxide dismutase and delta-aminolevulinic acid dehydratase in the liver and kidney of the diabetic animals (P0.05). Gallic acid treatment showed protective effects in these parameters evaluated, and also prevented a decrease in the activity of catalase and glutathione S-transferase, and vitamin C levels in the liver of diabetic rats. In addition, gallic acid reduced the number of nuclei and increased the area of the core in hepatic tissue, and increased the glomerular area in renal tissue. These results indicate that gallic acid can protect against oxidative stress-induced damage in the diabetic state. |
| Databáze: | OpenAIRE |
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