Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications
| Autor: | Kajal Tak, Vivek Dave, Kakarla Raghava Reddy, Ashish Gupta, Veera Sadhu, Amit Sohgaura |
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| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
Drug Biocompatibility Polymers media_common.quotation_subject Aptamer Nanoparticle Nanotechnology Microbiology 03 medical and health sciences Drug Delivery Systems Humans Nanobiotechnology Molecular Biology 030304 developmental biology media_common chemistry.chemical_classification 0303 health sciences Liposome 030306 microbiology Chemistry Polymer Lipids Nanomedicine Pharmaceutical Preparations Drug delivery Nanoparticles |
| Zdroj: | Journal of Microbiological Methods. 160:130-142 |
| ISSN: | 0167-7012 |
| Popis: | This review article is an updated overview on lipid-polymer hybrid nanoparticles (LPHNs) including the various types of LPHNs polymers used in their preparation, various methods of preparation, their physiochemical, in-vitro and in-vivo evaluation parameters and their application in various delivery systems. LPHNs show a combined advantage of biodegradable polymeric nanoparticles and liposomes. LPHNs mainly consist of a biodegradable polymeric material core containing drugs or any substances which are to be encapsulated then this core is further enclosed by a phospholipid layer i.e. lipid PEG layer. LPHNs show good physical strength and biocompatibility. The hybrid structural design can offer various benefits such as controlled particle size, high drug loading, surface functionality with various ligands (antibody fragments, peptides, monoclonal antibodies, aptamers, and folate molecules), and encapsulation of combinational therapeutic agents, showing prolonged release of drug and drug circulates in the blood for longer duration. Significantly, the LPHNs have recently been confirmed as a better drug delivery route and good cellular delivery efficacy of various drugs as compared to polymeric nanoparticles and liposomes. |
| Databáze: | OpenAIRE |
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