Metastatic dysgerminoma in a young patient with 46 XY DSD: A rare case report
| Autor: | Chandan Krushna Das, Surekha Thakur, Pooja Sikka, S.C. Saha, Kollabathula Arpitha, Uttam Kumar Thakur |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Disorders of sex development Exploratory laparotomy medicine.medical_treatment Case Report Dysgerminoma lcsh:Gynecology and obstetrics lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine medicine Etoposide lcsh:RG1-991 Chemotherapy 030219 obstetrics & reproductive medicine business.industry 46XY Obstetrics and Gynecology Karyotype medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Abdominal mass Tumor lysis syndrome Oncology 030220 oncology & carcinogenesis medicine.symptom business medicine.drug |
| Zdroj: | Gynecologic Oncology Reports, Vol 35, Iss, Pp 100693-(2021) Gynecologic Oncology Reports |
| ISSN: | 2352-5789 |
| Popis: | Highlights • A rare case of metastatic dysgerminoma in a young patient with 46XY DSD. • Incidence of DSD is 1:5000 with 90% of patients having 46XX chromosome and only 10% have 46 XY chromosome. • Individuals with an underlying DSD, especially with Y chromosome have an increased risk of developing germ cell tumor. • Dysgerminoma is highly chemosensitive tumor. • Multidisciplinary approach is required in management of such cases. The term DSD (Disorders of Sex development) is issued to define those conditions in whom disharmony exists between chromosomal, hormonal and anatomical sex. Parental and patient mental health and quality of life are adversely affected by these conditions. Moreover, individuals with an underlying DSD, especially those with specific Y chromosomal material in their karyotype have an increased risk for developing a germ cell tumor. Here, we present a unique case of 46XY DSD with bilateral dysgerminomas presenting with abdominal mass at the age of 24 years, who was treated with one cycle of chemotherapy comprising of Carboplatin and Etoposide, following which he developed tumor lysis syndrome and later underwent exploratory laparotomy. |
| Databáze: | OpenAIRE |
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