Pre-operative Detection of Liver Fibrosis in Hepatocellular Carcinoma Patients Using 2D Shear Wave Elastography: Where to Measure?
| Autor: | Tian'an Jiang, Jiong-Hui Gu, Li-Ting Xie, Qiyu Zhao, Rendong Chen, Weilu Chai, Dexing Kong |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Acoustics and Ultrasonics Liver fibrosis Biophysics Hepatitis 03 medical and health sciences 0302 clinical medicine Preoperative Care medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Aged Neoplasm Staging Shear wave elastography Radiological and Ultrasound Technology Receiver operating characteristic business.industry Liver Neoplasms Middle Aged medicine.disease Pre operative ROC Curve 030220 oncology & carcinogenesis Hepatocellular carcinoma Elasticity Imaging Techniques Female 030211 gastroenterology & hepatology Radiology Hepatic fibrosis business |
| Zdroj: | Ultrasound in Medicine & Biology. 46:1412-1423 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2020.02.012 |
| Popis: | The aim of this study was to pre-operatively investigate the diagnostic performance of 2D shear wave elastography (2D-SWE) for staging liver fibrosis and inflammation in patients with hepatocellular carcinoma (HCC) who then undergo surgery and to determine the optimal locations for measurement. In total, 106 patients were enrolled in this prospective study from March 2017 to May 2018. Two-dimensional SWE was used to measure liver stiffness (LS) in each patient 0-1, 1-2 and 2-5 cm from the tumor border (groups 1, 2 and 3, respectively). Spearman's correlation was used to evaluate the relationships between LS and hepatic fibrosis and between LS and inflammation. Receiver operating characteristic curve (ROC) analysis was used to evaluate the diagnostic accuracy of 2D-SWE. The technical success rate of SWE in tissue distant from the tumor (group 3) was significantly higher than that in peri-tumoral tissue (groups 1 and 2) (p < 0.001). Moreover, the area under the ROC for diagnosing cirrhosis (F4) and severe inflammation (A3) was higher for group 3 than for groups 1 and 2. Our results suggest that 2D-SWE is a helpful approach to assessment of hepatic fibrosis in HCC patients before hepatic resection. We found that to achieve a superior success rate and preferable diagnosis accuracy for patients with HCC, LS measurement should be performed 2-5 cm from the tumor margin. |
| Databáze: | OpenAIRE |
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