A and B Blood Group Antigens in Human Pancreatic Ductal Adenocarcinomas
| Autor: | Adriana Handra-Luca |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Adenocarcinoma Blood group antigens Immunoenzyme Techniques Pancreatectomy Biomarkers Tumor medicine Carcinoma Humans In patient Pancreatic carcinoma Survival rate Aged Neoplasm Staging Aged 80 and over business.industry General Medicine Middle Aged Prognosis medicine.disease Pancreatic Neoplasms Survival Rate medicine.anatomical_structure Oncology Lymphatic Metastasis Blood Group Antigens Female Pancreas business Carcinoma Pancreatic Ductal Follow-Up Studies |
| Zdroj: | Oncology. 84:141-149 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Objectives: The aim of this study was to determine the clinicopathological significance of blood group expression patterns in patients with surgically resected pancreatic ductal adenocarcinomas. Methods: Pancreatic ductal adenocarcinomas from 459 patients were analyzed for immunohistochemical expression of A and B blood group antigens on tissue microarrays. Correlations were established by Fisher’s test, χ2 test, and logistic regression models, and relationships to postsurgical overall survival were analyzed by Kaplan-Meier method, log-rank test, and multivariate Cox models. Results: Tumors expressing blood group A antigen predicted fewer lymph node metastases (Conclusion: In patients with resectable pancreatic ductal adenocarcinomas, blood group A antigen expression predicted fewer lymph node metastases and was associated with improved outcome after pancreaticoduodenectomy. |
| Databáze: | OpenAIRE |
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