Direct electrical stimulation using a battery-operated device for induction and modulation of colonic contractions in pigs
| Autor: | Steve Aellen, Aris D’Ambrogio, Nicolas Peloponissios, Jean-Claude Givel, Nathalie Virag, P. Wiesel, Vincent Schlageter, Jean-Marc Vesin, Mattia Bertschi, Pavel Kucera |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Chemistry Colon Swine Biomedical Engineering Stimulation Electric Stimulation Surgery Cecum medicine.anatomical_structure Electric Power Supplies In vivo Intraluminal pressure medicine Animals Feasibility Studies Female Electrodes Maximum amplitude Biomedical engineering |
| Zdroj: | Annals of biomedical engineering. 38(7) |
| ISSN: | 1573-9686 |
| Popis: | Direct electrical stimulation of the colon offers a promising approach for the induction of propulsive colonic contractions by using an implantable device. The objective of this study was to assess the feasibility to induce colonic contractions using a commercially available battery-operated stimulator (maximum pulse width of 1 ms and maximum amplitude of 10 V). Three pairs of pacing electrodes were inserted into the cecal seromuscular layer of anesthetized pigs. During a first set of in vivo experiments conducted on six animals, a pacing protocol leading to cecum contractions was determined: stimulation bursts with 1 ms pulse width, 10 V amplitude (7-15 mA), 120 Hz frequency, and 30-s burst duration, repeated every 2-5 min. In a second testing phase, an evaluation of the pacing protocol was performed in four animals (120 stimulation bursts in total). By using the battery-operated stimulator, contractions of the cecum and movement of contents could be induced in 92% of all stimulations. A cecal shortening of about 30% and an average intraluminal pressure increase of 10.0 +/- 6.0 mmHg were observed. |
| Databáze: | OpenAIRE |
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