Adiponectin and Cardiac Hypertrophy in Acromegaly
| Autor: | Guzin Fidan Yaylali, Senay Topsakal, Halil Tanriverdi, Sabriye Gurbulak, Beyza Akdag, Fulya Akin, Emrah Yerlikaya, Bunyamin Kaptanoglu |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male medicine.medical_treatment Medicine (miscellaneous) insulin blood level Blood Pressure heart ventricle ejection time heart function 0302 clinical medicine early transmitral maximal flow velocity atrial transmitral maximal flow velocity ratio insulin resistance middle aged Acromegaly/*blood/physiopathology Adiponectin/*blood Adult Analysis of Variance Blood Glucose/metabolism Blood Pressure/physiology Cardiomegaly/*blood/physiopathology Female Growth Hormone/blood Humans Insulin/blood Insulin Resistance/physiology Insulin-Like Growth Factor I/metabolism Intra-Abdominal Fat/metabolism Middle Aged echocardiography Insulin Pharmacology (medical) Mass index Insulin-Like Growth Factor I pathophysiology Genetics (clinical) clinical article heart ventricle hypertrophy predictive value adult velocity of mitral flow propagation acromegaly cardiac hypertrophy Cardiac hypertrophy female medicine.anatomical_structure cardiomegaly ADIPOQ protein human Adiponectin interventricular septum thickness hormones hormone substitutes and hormone antagonists Cardiac function curve analysis of variance medicine.medical_specialty left ventricular posterior wall thickness Cardiomegaly 030209 endocrinology & metabolism Intra-Abdominal Fat isovolumetric relaxation time Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Insulin resistance blood Internal medicine Acromegaly Internal Medicine medicine cardiovascular parameters controlled study human intraabdominal fat deceleration time adiponectin business.industry heart left ventricle mass medicine.disease somatomedin C glucose blood level Endocrinology Ventricle Growth Hormone physiology Reviews and References (medical) heart left ventricle endsystolic volume Insulin Resistance business metabolism heart left ventricle enddiastolic volume heart left ventricle ejection fraction 030215 immunology Hormone |
| Zdroj: | Advances in Clinical and Experimental Medicine. 25:449-455 |
| ISSN: | 1899-5276 |
| DOI: | 10.17219/acem/35639 |
| Popis: | Background. Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied. Objectives. The aim of this study was to find out how adiponectin levels were affected in acromegalic patients and the relationship between adiponectin levels and cardiac parameters. Material and Methods. We included 30 subjects (15 male, 15 female), diagnosed with acromegaly and 30 healthy (10 male, 20 female) subjects. Serum glucose, insulin, GH, IGF-1 and adiponectin levels were obtained and the insulin resistance of the subjects was calculated. Echocardiographic studies of the subjects were performed. Results. We determined that adiponectin levels were significantly higher in the acromegalic group than the control group. In the acromegalic group, there was no statistically significant relation between serum adiponectin and growth hormone (GH), or insulin-like growth factor-1 (IGF-1) levels (p = 0.3, p = 0.1). We demonstrated that cardiac function and structure are affected by acromegaly. IVST, PWT, LVMI, E/A ratio, DT, ET, IVRT, VPR, and LVESV values were increased and the results were statistically significant. In the acromegalic group, adiponectin levels were positively related with left ventricle mass index (LVMI) but this correlation was found to be statistically weak (p = 0.03). In our study, there was a positive correlation between VAI and LVM. We also could not find any correlation between VAI and adiponectin levels. Conclusions. Although insulin resistance and high insulin levels occur in active acromegaly patients, adiponectin levels were higher in our study as a consequence of GH lowering therapies. Our study showed that adiponectin levels may be an indicator of the cardiac involvement acromegaly. However, the usage of serum adiponectin levels in acromegalic patients as an indicator of cardiac involvement should be supported with other, wide, multi-centered studies. © Copyright by Wroclaw Medical University. |
| Databáze: | OpenAIRE |
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