Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds
| Autor: | Zhi-Yun Liu, Silas P. Cook |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Org Lett |
| Popis: | Herein, we describe the nickel-catalyzed reductive arylation of remote C(sp(3))–H bonds with aryl electrophiles. The reaction targets secondary and tertiary C(sp(3))–H bonds to deliver all-carbon quaternary centers. The success of this method relies on a novel amidyl radical precursor that tolerates reducing conditions, namely O-oxalate hydroxamic acid esters. |
| Databáze: | OpenAIRE |
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