Gap junctions in Drosophila: developmental expression of the entire innexin gene family
Autor: | Martin G. Todman, Kirsten Jacobs, Lucy A. Stebbings, Jennifer L.Y. Tam, Jonathan P. Bacon, Pauline Phelan, Claire E. Greer, Rose J Phillips, Jane A. Davies |
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Rok vydání: | 2002 |
Předmět: |
Central Nervous System
Embryology DNA Complementary Molecular Sequence Data Connexin Gene Expression Innexin Gating Chromosomes Connexins Retina Gene family Animals Drosophila Proteins Wings Animal Amino Acid Sequence RNA Messenger In Situ Hybridization Phylogeny Whole genome sequencing Genetics biology Models Genetic Sequence Homology Amino Acid Gap junction biology.organism_classification Cell biology Drosophila melanogaster Heterologous expression Developmental Biology |
Zdroj: | Mechanisms of development. 113(2) |
ISSN: | 0925-4773 |
Popis: | Invertebrate gap junctions are composed of proteins called innexins and eight innexin encoding loci have been identified in the now complete genome sequence of Drosophila melanogaster. The intercellular channels formed by these proteins are multimeric and previous studies have shown that, in a heterologous expression system, homo- and hetero-oligomeric channels can form, each combination possessing different gating characteristics. Here we demonstrate that the innexins exhibit complex overlapping expression patterns during oogenesis, embryogenesis, imaginal wing disc development and central nervous system development and show that only certain combinations of innexin oligomerization are possible in vivo. This work forms an essential basis for future studies of innexin interactions in Drosophila and outlines the potential extent of gap-junction involvement in development. |
Databáze: | OpenAIRE |
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