Examination of the Differential Characteristics of Amplifier and Contrasuppressor T Cells
| Autor: | Michael B. Fauntleroy, Benjamin Prescott, Phillip J. Baker |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
T-Lymphocytes
Immunology Spleen Lymphocyte Activation T-Lymphocytes Regulatory law.invention Mice Antigen law Lectins Cell Adhesion Animals Immunology and Allergy Medicine B-Lymphocytes Mice Inbred BALB C Immunological paralysis business.industry Polysaccharides Bacterial Hematology Antibodies Bacterial medicine.anatomical_structure Antibody response Immunization Suppressor Female business |
| Zdroj: | Immunobiology. 177:438-448 |
| ISSN: | 0171-2985 |
| DOI: | 10.1016/s0171-2985(88)80010-x |
| Popis: | Vicia villosa lectin-adherent Lyt-1 + spleen cells, obtained 4 days after immunization with an optimally immunogenic dose (0.5 υg) of Type III pneumococcal polysaccharide (SSS-III), increased the magnitude of the antibody response of mice to SSS-III upon transfer to recipients also immunized with the same antigen; however, the ability to demonstrate such enhancement depended greatly upon when such cells were transferred relative to immunization of recipients. Lectin-adherent cells augmented the antibody response of athymic nude (nu/nu) mice to SSS-III, and abrogated the expression - but not the induction - of low-dose immunological paralysis, a form of unresponsiveness mediated by suppressor T cells. These findings are consistent with effects usually attributed to the action of amplifier, rather than contrasuppressor, T cells. |
| Databáze: | OpenAIRE |
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