Simulating nephron ion transport function using activated wafer electrodeionization
| Autor: | Grace Morrison, Sam Stephens, Ira Kurtz, Jamie A. Hestekin, Sadia Paracha, Catey Atchley, John P. Moore, Christa N. Hestekin, Efecan Pakkaner, Leticia Santos de Souza |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
urogenital system Chemistry 030232 urology & nephrology Nephron Glomerulus (kidney) urologic and male genital diseases Artificial kidney End stage renal disease 03 medical and health sciences Ultrafiltration (renal) 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Mechanics of Materials TA401-492 Biophysics medicine General Materials Science Nanofiltration Electrodeionization Materials of engineering and construction. Mechanics of materials Ion transporter |
| Zdroj: | Communications Materials, Vol 1, Iss 1, Pp 1-10 (2020) |
| ISSN: | 2662-4443 |
| Popis: | Current approaches for treating patients with end stage renal disease include hemodialysis and peritoneal dialysis, both of which are diffusion-based treatments that require a dialysate solution. The native kidney has separate filtration (glomerulus) and transport (nephron) capabilities. Although artificial methods for simulating glomerular function using membrane ultrafiltration have been proposed, there are no known technologies for simulating the ion transport functions of the nephron. Here we have created a synthetic nephron using activated wafer electrodeionization (AWEDI). AWEDI incorporates mesh electrodes within an electrodeionization wafer, allowing ion selectivity and transport rate to be modulated independently. We demonstrate the capabilities of AWEDI with several physiologically relevant ions which mimic the fine control of ion transport by the kidney. Furthermore, by integrating our AWEDI technology with ultrafiltration, nanofiltration, and reverse osmosis modules, the possibility of incorporating AWEDI technology in an artificial kidney is demonstrated. The nephrons in the kidney transport ions and organic molecules, but may not work effectively in patients with kidney disease. Here, a synthetic nephron is created, based on activated wafer electrodeionization, and shown to enable the transport of several physiologically relevant ions. |
| Databáze: | OpenAIRE |
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