Outcomes for Patients With Cervical Cancer Treated With Extended-Field Intensity-Modulated Radiation Therapy and Concurrent Cisplatin
Autor: | Michael D. Hasselle, Catheryn M. Yashar, Daniel J. Scanderbeg, Sameer K. Nath, Yasmin Hasan, Lindsay G. Jensen, Brent S. Rose, Arno J. Mundt, Loren K. Mell |
---|---|
Rok vydání: | 2013 |
Předmět: |
Adult
Oncology medicine.medical_specialty medicine.medical_treatment Uterine Cervical Neoplasms Young Adult Internal medicine Humans Medicine Cumulative incidence Aged Retrospective Studies Cervical cancer Cisplatin business.industry Genitourinary system Obstetrics and Gynecology Common Terminology Criteria for Adverse Events Chemoradiotherapy Middle Aged medicine.disease Survival Analysis Confidence interval Radiation therapy Treatment Outcome Case-Control Studies Toxicity Carcinoma Squamous Cell Female Radiotherapy Intensity-Modulated business medicine.drug |
Zdroj: | International Journal of Gynecologic Cancer. 23:119-125 |
ISSN: | 1525-1438 1048-891X |
Popis: | ObjectiveTo evaluate disease outcomes and toxicity in patients with cervical cancer treated with extended-field intensity-modulated radiotherapy.Materials and MethodsWe included all patients treated with extended-field intensity-modulated radiotherapy and concurrent weekly cisplatin from 2003 to 2010 at 2 institutions. Overall survival and disease-free survival were estimated using Kaplan-Meier method. Locoregional failure (LRF), distant failure, and competing mortality were calculated using cumulative incidence functions. Acute and late toxicity were graded using Common Terminology Criteria for Adverse Events (CTCAE) and Radiation Therapy Oncology Group late radiation morbidity scoring criteria, respectively.ResultsThe study included 21 patients, 14 and 20 of which had positive para-aortic and pelvic nodes, respectively. The median follow-up was 22 months. Eighteen-month overall survival and disease-free survival were 59.7% (95% confidence interval [CI], 41.2%–86.4%) and 42.9% (95% CI, 26.2%–70.2%). Eighteen-month cumulative incidences of LRF, distant failure, and competing mortality were 9.5% (95% CI, 1.5–26.8%), 42.9% (95% CI, 21.3–62.9%), and 4.8% (95% CI, 0.3–20.2%), respectively. Eighteen-month cumulative incidences of late grade 3 or higher-grade genitourinary and gastrointestinal toxicity were 4.8% (95% CI, 0.2%–20.3%) and 0%, respectively.ConclusionsIntensity-modulated extended-field radiotherapy was associated with low rates of late toxicity and LRF. High rates of distant failure indicate that this group of patients could benefit from intensified systemic therapy. |
Databáze: | OpenAIRE |
Externí odkaz: |