Orlistat accentuates the fat-induced fall in blood pressure in older adults
| Autor: | Kamilia Tai, Diana Gentilcore, Angela J. Hammond, Michael Horowitz, Odd Helge Gilja, Ian Chapman, Karen L. Jones, Lisa Banh, Christine Feinle-Bisset |
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| Přispěvatelé: | Tai, Kamilia, Gentilcore, Diana, Jones, Karen L, Banh, Lisa, Gilja, Odd Helge, Hammond, Angela J, Feinle-Bisset, Christine, Horowitz, Michael, Chapman, Ian M |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty postprandial hypotension Medicine (miscellaneous) Blood Pressure elderly Lactones Heart Rate fat Internal medicine Heart rate Humans Medicine Ingestion cardiovascular function Aged Aged 80 and over Orlistat Nutrition and Dietetics Gastric emptying business.industry Stomach Postprandial Period Dietary Fats Lipids Blood pressure medicine.anatomical_structure Endocrinology Postprandial Gastric Emptying Lipase inhibitors Female Hypotension business medicine.drug |
| Zdroj: | British Journal of Nutrition. 106:417-424 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s000711451100016x |
| Popis: | Postprandial hypotension may be influenced by the digestion of fat. The aim of the present study was to evaluate the hypothesis that products of fat digestion mediate the hypotensive response to fat. In part A of the study, nine healthy older subjects were studied on three separate occasions in randomised order. Blood pressure, heart rate (HR), plasma TAG and gastric emptying were measured following the ingestion of equivolaemic drinks: (1) 300 ml of high-fat drink (88 % fat); (2) fat drink mixed with 120 mg orlistat (lipase inhibitor); (3) water (control). In part B of the study, ten healthy older subjects were studied on two separate occasions. Blood pressure, HR, plasma TAG and superior mesenteric artery flow were measured during 90 min intraduodenal infusions of 10 % intralipid (2·7 ml/min), with and without 120 mg orlistat. Oral fat ingestion was associated with decreases in systolic and diastolic blood pressures (both P = 0·0001) that were greater when orlistat was co-administered (both P P = 0·0001) that was inhibited by orlistat co-administration (P P P P |
| Databáze: | OpenAIRE |
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